PUBLICATION
Insights into sensory hair cell regeneration from the zebrafish lateral line
- Authors
- Kniss, J.S., Jiang, L., Piotrowski, T.
- ID
- ZDB-PUB-160610-22
- Date
- 2016
- Source
- Current opinion in genetics & development 40: 32-40 (Review)
- Registered Authors
- Jiang, Linjia, Kniss, Jonathan, Piotrowski, Tatjana
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Differentiation/genetics*
- Cell Proliferation/genetics*
- Ear, Inner/growth & development
- Ear, Inner/injuries
- Hair Cells, Auditory/metabolism*
- Humans
- Receptors, Notch/genetics
- Regeneration/genetics*
- Wnt Signaling Pathway/genetics
- Zebrafish/genetics
- Zebrafish/growth & development
- PubMed
- 27266973 Full text @ Curr. Opin. Genet. Dev.
Citation
Kniss, J.S., Jiang, L., Piotrowski, T. (2016) Insights into sensory hair cell regeneration from the zebrafish lateral line. Current opinion in genetics & development. 40:32-40.
Abstract
Loss of mechanosensory hair cells in the inner ear leads to loss of hearing. In humans this results in permanent deafness, as mammals are largely unable to regenerate hair cells. In contrast, zebrafish robustly regenerate hair cells in the sensory lateral line and ear and recent gene expression and time-lapse analyses of cell behaviors at the single cell level have greatly advanced our understanding of the mechanisms responsible for hair cell regeneration. In the lateral line, hair cell regeneration is controlled via dynamic interactions between Notch and Wnt/β-catenin signaling, and likely also between Fgf and the retinoic acid signaling pathways. Less is known about what initiates regeneration and we discuss potential pathways that may trigger proliferation after hair cell damage.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping